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Efficacy and Safety of SSRI’s, SNRI’s, and Placebo for Common Psychiatric Disorders Among Children and Adolescents

Although research has proven the clinical efficacy of antidepressants in children and adolescents, it has also frequently reported the side effects. What is more, the influence of the placebo effect on the efficacy of antidepressants is unclear. A meta-analysis from over 6,500 patients has shown that, although antidepressants are more effective than placebos, the difference is minor and varies according to the type of mental disorder (most common mental disorders include anxiety disorders, depressive disorders, obsessive-compulsive disorder, and posttraumatic stress disorder). The treatment which includes psychotherapy together with antidepressants such as selective serotonin reuptake inhibitors (SSRIs) and serotonin-norepinephrine reuptake inhibitors (SNRIs) has been studied extensively in the below mentioned research. A few of the key aspects from research paper include:

  • antidepressants are seen to work better than placebos but have more side effects
  • the placebo effect was found to be stronger in cases of depression
  • individual clarification needed

Link to research paper: