A study in which sixty patients meeting Diagnostic and Statistical Manual of Mental Disorders (4th ed.; American Psychiatric Association, 1994) criteria for generalized social phobia were assigned to cognitive therapy (CT), fluoxetine plus self-exposure (FLU SE), or placebo plus self-exposure (PLA SE).
At post treatment (16 weeks), the medication blind was broken. CT and FLU SE patients then entered a 3-month booster phase. Assessments were at pretreatment, midtreatment, posttreatment, end of booster phase, and 12-month follow-up.
Significant improvements were observed on most measures in all 3 treatments. On measures of social phobia, CT was superior to FLU SE and PLA SE at mid treatment and at posttreatment. FLU SE and PLA SE did not differ. CT remained superior to FLU SE at the end of the booster period and at 12-month follow-up. On general mood measures, there were few differences between the treatments.
Link to research: Cognitive Therapy Versus Fluoxetine in Generalized Social Phobia