ELK-1 as a specific signalling module in depression…
In a study published by the Nature Medicine (link below), a team of scientists at McGill University and France’s Institut national de la santé et de la recherche médicale (INSERM) examined the biological and molecular mechanisms at play in neurons during treatment with a classical antidepressant.
The extracellular signal–regulated kinase (ERK) pathway is implicated in mood regulation, but its pleiotropic functions and lack of target specificity prohibit optimal drug development. The researchers identified the transcription factor ELK-1, an ERK downstream partner, as a specific signalling module in the pathophysiology and treatment of depression that can be targeted independently of ERK.
Link to research: https://www.nature.com/articles/s41591-018-0011-0