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Three Shades of Depression…

Researchers from the Neural Computational Unit at the Okinawa Institute of Science and Technology Graduate University in collaboration with their colleagues at Nara Institute of Science and Technology and clinicians at Hiroshima University have for the first time identified three sub-types of depression. Of the three sub-types of depression, one appeared to be untreatable by selective serotonin reuptake inhibitors (SSRIs), the most commonly prescribed medicines for the condition.

 The study sample included data (clinical, biological, and life history) collected from 134 participants. 67 participants were newly diagnosed with depression and the remaining 67 participants had no depression diagnosis.  Participants were also asked about their sleep patterns, whether or not they had stressful issues, or other mental health conditions.

The identified three distinct sub-types of depression are as follow:

  • D1: This sub-type is characterized by high functional connectivity of the brain and a history of childhood trauma.
  • D2: This sub-type is characterized by high functional connectivity of the brain and an absence of childhood trauma.
  • D3: This sub-type is characterized by both low functional connectivity of the brain and absence of childhood trauma.

Link to research: https://www.nature.com/articles/s41598-018-32521-z